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So exposure to asbestos can lead to Mesothelioma - nearly 80 percent of patients stated Mesothelioma have been exposed to asbestos - however, in about 20% of the Mesothelioma cases, patients have not evidently been exposed to asbestos, the cause for the desease in these cases is merely speculative. While smoking might advance Mesothelioma in connotation of asbestos, smoking alone does not evidently further the risk. For the record: currently however, there are no other known triggers for Mesothelioma.